ZeBlast is composed of clinical haematologist, pathologist and zebrafish scientists who share a common goal to improve and speed up drug discovery for blood cancers.
Professor Anskar Y H Leung | Finding a solution to blood cancers
At ZeBlast, we are determined to make a positive impact on patients globally who are affected by blood cancers. As Professor in haematology, we have witnessed firsthand the devastating effects of these diseases, and we understand the pressing need for more effective treatments. With blood cancer currently ranking as the fifth deadliest cancer worldwide, it’s clear that a new approach is urgently needed. That’s why we’re dedicated to innovating and developing new therapies that target the specific genetic abnormalities that cause blood cancers.
We recognize that the current lack of FDA-approved medications targeting these mutations slows down the development of effective treatments, and we’re committed to changing that. At ZeBlast, we believe that through collaboration and innovation, we can make a meaningful difference in the lives of patients around the world who are battling blood cancers.
Professor Anskar Y H Leung
Dr. Alvin C H Ma | State-of-the-art genome editing
Zebrafish is amendable to genetic manipulation and many edge-cutting in vivo genome engineering techniques are first developed with zebrafish model. Genetic materials (DNA or RNA), proteins and their complexes can be easily delivered into single-cell zebrafish embryo by direct microinjection.
Our team is experienced in zebrafish genome engineering. In particular, we have developed different technical platforms including CRISPR/Cas, TALEN and Transposon to perform in vivo gene knock-out, knock-in and precise gene editing, creating zebrafish genetic model of human diseases.
Dr. Alvin C H Ma
Dr. Sally X Sun | Beauty of zebrafish
In Zeblast, we use zebrafish to model human diseases, with a particular focus on blood cancers. Like humans, zebrafish are vertebrates, and they share around 80% of their genes to humans.
They also share many similarities in their biology to humans, including the organization of major organs, gene expression patterns, and physiological processes. The development of the blood system is also highly conserved between humans and zebrafish.
These similarities, combined with their transparent embryos, rapid development, and the availability of genetic tools, make them an excellent system for investigating the mechanisms of blood cancer development, testing for potential therapies, and drug discovery.
Dr. Sally X Sun
MS CHAN HIU HING
MS MANDY W.S. CHAN
HEAD OF ADMIN
MS EVA M.S WU
PROF. ERIC C.W. SO
Professor and Chair in Leukaemia Biology, Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, King’s College, London.
PROF. WENQING ZHANG
Associate Dean of School of Medicine, Head of Institution of Cell, Developmental & Integrative Biology Professor of South China University of Technology Guangzhou, China