4 FEBRUARY 2023
Isocitrate dehydrogenase 2 (IDH2) mutations occur in more than 15% of cytogenetically normal acute myeloid leukemia (CN-AML) but comparative studies of their roles in leukemogenesis have been scarce.
15 NOVEMBER 2022
Internal Tandem Duplication of human FMS-like tyrosine kinase (FLT3-ITD) is one of the most frequent genetic alterations in de novo acute myeloid leukemia (AML) and is often acquired during transformation of myelodysplastic syndrome (MDS) into AML, predicting an unfavorable prognosis.
15 NOVEMBER 2022
Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic neoplasm characterized by monocytosis and recurrent gene mutations including those of SRSF2, ASXL1, TET2, RUNX1
26 MARCH 2020
ADP-ribosylation factor-like 4aa (Arl4aa) is a member of the ADP-ribosylation factor family. It is expressed in hematopoietic tissue during embryonic development, but its function was unknown.
5 MARCH 2020
Internal tandem duplication of Fms-like tyrosine kinase 3 (FLT3/ITD) occurs in about 30% of acute myeloid leukemia (AML) and is associated with poor response to conventional treatment and adverse outcome.
1 JULY 2019
Acute myeloid leukaemia (AML) is a highly genetically heterogenous disease. Patients carry unique genetic mutational profile that affect their clinical outcome.
6 SEPTEMBER 2017
The recent advances in sequencing techniques revealed acute myeloid leukaemia (AML) as a highly genetically heterogeneous disease. Each patient carries unique genetic mutational profile which can predict the clinical outcome.
23 JULY 2017
The recent advent of next-generation sequencing (NGS) has greatly accelerated identification of gene mutations in myeloid malignancies at unprecedented speed that will soon outpace their functional validation by conventional laboratory techniques and animal models.
7 MAY 2015
Isocitrate dehydrogenase 1 mutation (IDH1-R132H) was recently identified in acute myeloid leukemia with normal cytogenetics. he mutant enzyme is thought to convert α-ketoglutarate to the pathogenic 2-hydroxyglutarate (2-HG) that affects DNA methylation via inhibition of ten-eleven translocation 2.
17 APRIL 2014
FMS-like tyrosine kinase 3 (FLT3) is expressed in human hematopoietic stem and progenitor cells (HSPCs) but its role during embryogenesis is unclear.
17 NOVEMBER 2011
In a chemical screening, we tested the antiangiogenic effects of fumagillin derivatives and identified fumagillin as an inhibitor of definitive hematopoiesis in zebrafish embryos.
7 OCTOBER 2010
Although aldehyde dehydrogenase (ALDH) activity has become a surrogate of hematopoietic stem and progenitor cells (HSPCs), its function during hematopoiesis was unclear.
8 JANUARY 2009
Survivin is an inhibitor of apoptosis and its role in embryonic development is not completely understood. In zebrafish, survivin undergoes gene duplication.